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In vivo continuous‐wave optical breast imaging enhanced with Indocyanine Green
Author(s) -
Intes Xavier,
Ripoll Jorge,
Chen Yu,
Nioka Shoko,
Yodh A. G.,
Chance Britton
Publication year - 2003
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1573791
Subject(s) - indocyanine green , diffuse optical imaging , in vivo , biomedical engineering , breast imaging , medical imaging , tomography , medicine , nuclear medicine , materials science , radiology , breast cancer , mammography , pathology , cancer , microbiology and biotechnology , biology
We investigate the uptake of a nontargeted contrast agent by breast tumors using a continuous wave diffuse optical tomography apparatus. The instrument operates in the near‐infrared spectral window and employs 16 sources and 16 detectors to collect light in parallel on the surface of the tumor‐bearing breast (coronal geometry). In our protocol an extrinsic contrast agent, Indocyanine Green (ICG), was injected by bolus. Three clinical scenarios with three different pathologies were investigated. A two‐compartment model was used to analyze the pharmacokinetics of ICG and preprocess the data, and diffuse optical tomography was used for imaging. Localization and delineation of the tumor was achieved in good agreement with a priori information. Moreover, different dynamical features were observed for differing pathologies. The malignant cases exhibited slower rate constants (uptake and outflow) compared to healthy tissue. These results provide further evidence that in vivo pharmacokinetics of ICG in breast tumors may be a useful diagnostic tool for differentiation of benign and malignant pathologies.