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Site‐specific variability in trabecular bone dosimetry: Considerations of energy loss to cortical bone
Author(s) -
Patton P. W.,
Rajon D. A.,
Shah A. P.,
Jokisch D. W.,
Inglis B. A.,
Bolch W. E.
Publication year - 2002
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1427083
Subject(s) - radionuclide , cortical bone , dosimetry , nuclear medicine , absorbed dose , materials science , chemistry , medicine , physics , anatomy , nuclear physics
With continual advances in radionuclide therapies, increasing emphasis is being placed on improving the patient specificity of dose estimates to marrow tissues. While much work has been focused on determining patient‐specific assessments of radionuclide uptake in the skeleton, few studies have been initiated to explore the individual variability of absorbed fraction data for electron and beta‐particle sources in various skeletal sites. The most recent values of radionuclide S values used in clinical medicine continue to utilize a formalism in which electrons are transported under a trabecular bone geometry of infinite extent. No provisions are thus made for the fraction of energy lost to the cortical bone cortex of the skeletal site and its surrounding tissues. In the present study, NMR microscopy was performed on trabecular bone samples taken from the femoral head and humeral proximal epiphysis of three subjects: a 51‐year male, an 82‐year female, and an 86‐year female. Following image segmentation and coupling to EGS4, electrons were transported within macrostructural models of the various skeletal sites that explicitly include the spatial extent of the spongiosa, as well as the thickness of the surrounding cortical bone. These energy‐dependent profiles of absorbed fractions to marrow tissues were then compared to transport simulations made within an infinite region of spongiosa. Ratios of mean absorbed fraction, as weighted by the beta energy spectra, under both transport methodologies were then assembled for the radionuclides32 P and90 Y . These ratios indicate that corrections to existing radionuclide S values for32 P can vary by as much as 5% for the male, 6% for the 82‐year female, and 8% for the 86‐year female. For the higher‐energy beta spectrum of90 Y , these same corrections can reach 8%, 10%, and 11%, respectively.