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Wavelength dependence of the precision of noninvasive optical measurement of oxy‐, deoxy‐, and total‐hemoglobin concentration
Author(s) -
Yamashita Yuichi,
Maki Atsushi,
Koizumi Hideaki
Publication year - 2001
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1373401
Subject(s) - wavelength , absorbance , measurement uncertainty , accuracy and precision , optics , laser , observational error , materials science , hemoglobin , noise (video) , chemistry , analytical chemistry (journal) , physics , mathematics , biochemistry , statistics , chromatography , quantum mechanics , artificial intelligence , computer science , image (mathematics)
The precision of noninvasive optical measurement of the concentration changes in oxy‐, deoxy‐, and total‐hemoglobin depends on wavelength. For estimating the precision, we calculated the noise level of the concentration changes as the uncertainty in measurements using several wavelength pairs of light. Seven laser diodes (664–848 nm) were used simultaneously for spectroscopic measurement of brain activity during finger motor stimulation. We also used the analysis of error propagation from the uncertainty in direct measurements of absorbance changes to estimate indirectly the uncertainty of concentration changes. The measurement of the concentration changes made using an 830/664‐nm pair are two times (oxy‐Hb) and six times (deoxy‐Hb) more precise than those made using an 830/782‐nm pair.