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A noninvasive dose estimation system for clinical BNCT based on PG‐SPECT—Conceptual study and fundamental experiments using HPGe and CdTe semiconductor detectors
Author(s) -
Kobayashi Tooru,
Sakurai Yoshinori,
Ishikawa Masayori
Publication year - 2000
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1288243
Subject(s) - semiconductor detector , neutron capture , dosimetry , nuclear medicine , detector , physics , absorbed dose , materials science , medical physics , neutron , optics , nuclear physics , medicine
A noninvasive method for measuring the absorbed dose distribution during the administration of clinical boron neutron capture therapy (BNCT) using an online three‐dimensional (3D) imaging system is presented. This system is designed to provide more accurate information for treatment planning and dosimetry. The single‐photon emission computed tomography (SPECT) technique is combined with prompt gamma‐ray analysis (PGA) to provide an ideal dose estimation system for BNCT. This system is termed PG‐SPECT. The fundamental feasibility of the PG‐SPECT system for BNCT is confirmed under the following conditions: (1) a voxel size of 1×1×1 cm 3 , comparable to the spatial resolution of our standard dosimetric technique using gold wire activation, where data are available for every 5–10 mm of wire length; (2) a reaction rate of10 B ( n , α ) 7 Li within the measurement volume is greater than1.1 × 10 6 interactions / cm 3/ s , corresponding to a thermal neutron flux of5 × 10 8 n / cm 2/ s and a10 B concentration of greater than 10 ppm for the deepest part of the tumor volume under typical BNCT clinical conditions; (3) statistical uncertainty of the count rate for10 B ( n , α ) 7 Li prompt gamma rays is 10% or less. The desirable characteristics of a detector for the PG‐SPECT system were determined by basic experiments using both HPGe and CdTe semiconductor detectors. The CdTe semiconductor detector has the greatest potential for this system because of its compactness and simplicity of maintenance.