Label-free imaging of arterial tissues using photonic crystal fiber (PCF) based nonlinear optical microscopic system | Zendy

Alex C.T. Ko | Zendy; Andrew Ridsdale | Zendy; Adrian F. Pegoraro | Zendy; Michael S. Smith | Zendy; Leila B. Mostaço-Guidolin | Zendy; Mark Hewko | Zendy; Elicia Kohlenberg | Zendy; Bernie Schattka | Zendy; Masashi Shiomi | Zendy; Albert Stolow | Zendy; Michael G. Sowa | Zendy

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Label-free imaging of arterial tissues using photonic crystal fiber (PCF) based nonlinear optical microscopic system

Author(s) -

Alex C.T. Ko,

Andrew Ridsdale,

Adrian F. Pegoraro,

Michael S. Smith,

Leila B. Mostaço-Guidolin,

Mark Hewko,

Elicia Kohlenberg,

Bernie Schattka,

Masashi Shiomi,

Albert Stolow,

Michael G. Sowa

Publication year - 2009

Publication title -

proceedings of spie, the international society for optical engineering/proceedings of spie

Language(s) - English

Resource type - Conference proceedings

SCImago Journal Rank - 0.192

H-Index - 176

eISSN - 1996-756X

pISSN - 0277-786X

DOI - 10.1117/12.809361

Subject(s) - optical sectioning , materials science , microscopy , microscope , elastin , optics , biomedical engineering , endomicroscopy , photonic crystal fiber , optical microscope , optoelectronics , scanning electron microscope , pathology , confocal , wavelength , medicine , physics , composite material

Nonlinear optical (NLO) microscopy provides a minimally invasive optical method for fast molecular imaging at subcellular resolution with 3D sectioning capability in thick, highly scattering biological tissues. In the current study, we demonstrate the imaging of arterial tissue using a nonlinear optical microscope based on photonic crystal fiber and a single femto-second oscillator operating at 800nm. This NLO microscope system is capable of simultaneous imaging extracellular elastin/collagen structures and lipid distribution within aortic tissue obtained from coronary atherosclerosis-prone WHHLMI rabbits (Watanabe heritable hyperlipidemic rabbit-myocardial infarction) Clear pathological differences in arterial lumen surface were observed between healthy arterial tissue and atherosclerotic lesions through NLO imaging.Peer reviewed: YesNRC publication: Ye

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