Open AccessCherenkov imaging for total skin electron therapy: an evaluation of dose uniformity
Author(s) -
Timothy C. Zhu,
Yi Hong Ong,
Hui Sun,
Weili Zhong,
Tianshun Miao,
Andreea Dimofte,
Petr Brůža,
Amit Maity,
John P. Plastaras,
Ima Paydar,
Lei Dong,
Brian W. Pogue
Publication year - 2021
Publication title -
pubmed central
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.192
H-Index - 176
pISSN - 0277-786X
DOI - 10.1117/12.2583939
Subject(s) - cherenkov radiation , scintillator , nuclear medicine , optics , radiation , physics , photon , medicine , detector
Total Skin Electron Therapy (TSET) utilizes high-energy electrons to treat cancers on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high-energy electron beam and tissue. Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real-time using a time-gated intensified camera system. Each patient was monitored during TSET by in-vivo detectors (IVD) as well as Scintillators. Patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. A rigorous methodology for converting Cherenkov intensity to surface dose as products of correction factors, including camera vignette correction factor, incident radiation correction factor, and tissue optical properties correction factor. A comprehensive study has been carried out by inspecting various positions on the patients such as vertex, chest, perineum, shins, and foot relative to the umbilicus point (the prescription point).