Open AccessEstimating paired-agent uptake in altered tumor vasculature using MRI-coupled fluorescence tomography
Author(s) -
Boyu Meng,
Rendall R. Strawbridge,
Kenneth M. Tichauer,
Kimberley S. Samkoe,
Scott C. Davis
Publication year - 2020
Publication title -
pubmed central
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.192
H-Index - 176
pISSN - 0277-786X
DOI - 10.1117/12.2546702
Subject(s) - angiogenesis , in vivo , glioma , medicine , cancer therapy , cancer , antiangiogenic therapy , cancer research , cancer treatment , pharmacology , pathology , biology , microbiology and biotechnology
Angiogenesis inhibiting cancer therapy has become a standard treatment for many cancer types. The ability to examine the effects of these drugs in tumors noninvasively could help assess efficacy early in the treatment course or identify optimal times to introduce other combinatorial treatments. Herein, we examine whether a paired agent MRI-coupled fluorescence tomography approach can be used to monitor the effects of anti-angiogenesis therapy. Using small animal models bearing orthotopic glioma xenografts, we demonstrate noninvasive quantification of paired-agent uptake in response to anti-angiogenesis therapy in vivo. The result provides insights on receptor targeted drug delivery in altered vasculature, a potential important development for treatment monitoring and combinatorial strategies.