Open AccessAdipose stem cells for bone tissue repair
Author(s) -
Simone Ciuffi,
Roberto Zonefrati,
Maria Luisa Brandi
Publication year - 2017
Publication title -
clinical cases in mineral and bone metabolism
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.314
H-Index - 32
eISSN - 1971-3266
pISSN - 1724-8914
DOI - 10.11138/ccmbm/2017.14.1.217
Subject(s) - adipose tissue , stromal cell , stem cell , stem cell transplantation for articular cartilage repair , bone marrow , tissue engineering , microbiology and biotechnology , clinical uses of mesenchymal stem cells , amniotic stem cells , adult stem cell , endothelial stem cell , regenerative medicine , biology , pathology , medicine , cancer research , immunology , endocrinology , in vitro , genetics , biochemistry
Adipose-derived stem/stromal cells (ASCs), together with adipocytes, vascular endothelial cells, and vascular smooth muscle cells, are contained in fat tissue. ASCs, like the human bone marrow stromal/stem cells (BMSCs), can differentiate into several lineages (adipose cells, fibroblast, chondrocytes, osteoblasts, neuronal cells, endothelial cells, myocytes, and cardiomyocytes). They have also been shown to be immunoprivileged, and genetically stable in long-term cultures. Nevertheless, unlike the BMSCs, ASCs can be easily harvested in large amounts with minimal invasive procedures. The combination of these properties suggests that these cells may be a useful tool in tissue engineering and regenerative medicine.