Open AccessPeriodontitis and bone metabolism
Author(s) -
Luigi Barbato,
Edoardo Francioni,
Massimiliano Bianchi,
E. Mascitelli,
Leila Brancato Marco,
Duvina Paolo Tonelli
Publication year - 2015
Publication title -
clinical cases in mineral and bone metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.314
H-Index - 32
eISSN - 1971-3266
pISSN - 1724-8914
DOI - 10.11138/ccmbm/2015.12.2.174
Subject(s) - osteoimmunology , periodontitis , bone remodeling , immune system , rankl , bone resorption , dental alveolus , osteoporosis , host response , immunology , osteolysis , medicine , neuroscience , biology , pathology , dentistry , receptor , activator (genetics)
Periodontitis is a plaque induced disease characterized by tissue destruction. The extent of the alveolar bone loss depends on the host response stimulated by bacterial infection. Recently researchers have focused on the role of the immune system, of RANK/RANKL/OPG pathway and of cytokines network. Another recent field of interest is osteoimmunology that try to explain the relationship between immune and bone cells in activating bone resorption. Advances in the understanding of the pathogenic mechanisms allowed a better understanding of the relationship with other diseases like osteoporosis and also to hypothesize new therapies based on modulation of host response (host modulatory therapy - HMT). The purpose of this mini-review is to briefly discuss these topics.