Open AccessEFFECTS OF PLANT PREPARATIONS OF PURE SAPONINS AND METHOXYFLAVONOIDS ON THE EXPRESSION OF IMMUNE RESPONSE GENES
Author(s) -
Aizhan Turmagambetova,
A.P. Bogoyavlenskyi,
Pavel Alexyuk,
Madina Alexyuk,
E.S. Omirtaeva,
Nadezhda S. Sokolova,
Irina A. Zaitseva,
V.E. Berezin
Publication year - 2019
Publication title -
eurasian journal of applied biotechnology
Language(s) - English
Resource type - Journals
eISSN - 2617-1147
pISSN - 2617-1139
DOI - 10.11134/btp.1.2019.6
Subject(s) - immune system , polygonum , saponin , betulin , biology , botany , polygonaceae , gene expression , traditional medicine , gene , biochemistry , immunology , medicine , ecology , alternative medicine , pathology
Studies on the immunostimulating properties of saponins and methoxyflavonoids obtained from plants provides a theoretical basis for development of new immunopotentiators, thereby increasing effectiveness of immunotherapy and prophylaxis of viral infections. Expression of major genes of the immune response were significantly up-regulated upon introduction of plant-based immunostimulators into the body. These compounds were a mixture of purified saponin betulin isolated from plants of Betula sp. (Betula pendula) and purified methoxyflavonoids of plants of Polygonum sp. (Polygonum persicaria) and Cytrus sp. (Cytrus sinensis). The strength and specificity of the body's immune response can be adjusted by changing the structure of the methoxyflavonoid in the complex immunostimulator, which makes it possible to stimulate targeted immunostimulators that act on certain parts of the immune system.