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In the beginning: a personal reminiscence on the origin and legacy of ClC‐0, the ‘ Torpedo Cl − channel’
Author(s) -
Miller Christopher
Publication year - 2015
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2014.286260
Subject(s) - reminiscence , channel (broadcasting) , torpedo , identity (music) , personal account , engineering , chemistry , psychology , telecommunications , philosophy , aesthetics , art , literature , cognitive psychology , biochemistry , acetylcholine receptor , receptor , narrative
This unapologetically subjective essay recalls the Torpedo Cl – channel in the years when it had neither a molecular identity nor proper name (ClC‐0), and membership in a large superfamily. I discuss the circumstances surrounding its discovery and subsequent research through the 1980s that revealed its unusual molecular architecture and other strange mechanistic characteristics.