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Na + channel function, regulation, structure, trafficking and sequestration
Author(s) -
ChenIzu Ye,
Shaw Robin M.,
Pitt Geoffrey S.,
YarovYarovoy Vladimir,
Sack Jon T.,
Abriel Hugues,
Aldrich Richard W.,
Belardinelli Luiz,
Cannell Mark B.,
Catterall William A.,
Chazin Walter J.,
Chiamvimonvat Nipavan,
Deschenes Isabelle,
Grandi Eleonora,
Hund Thomas J.,
Izu Leighton T.,
Maier Lars S.,
Maltsev Victor A.,
Marionneau Celine,
Mohler Peter J.,
Rajamani Sridharan,
Rasmusson Randall L.,
Sobie Eric A.,
Clancy Colleen E.,
Bers Donald M.
Publication year - 2015
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2014.281428
Subject(s) - channel (broadcasting) , function (biology) , sodium channel , structure function , political science , computer science , physics , sodium , chemistry , telecommunications , microbiology and biotechnology , biology , organic chemistry , particle physics
This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na + channel and Na + transport . The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na + channel function and regulation, Na + channel structure and function, and Na + channel trafficking, sequestration and complexing.