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CrossTalk proposal: Rotors have been demonstrated to drive human atrial fibrillation
Author(s) -
Narayan Sanjiv M.,
Jalife José
Publication year - 2014
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2014.271031
Subject(s) - atrial fibrillation , limiting , medicine , intensive care medicine , cardiology , asymptomatic , engineering , mechanical engineering
It is our pleasure to debate this important and clinically relevant topic. Atrial fibrillation (AF) is a leading cause of hospitalization and death (Calkins et al. 2012), and the need to improve AF therapy is urgent and requires dramatic advances in our mechanistic understanding. Decades of research have not dented the incidence of AF, now at epidemic proportions (Calkins et al. 2012), nor reduced its morbidity and mortality with the laudable exception of antithrombotic therapy (Calkins et al. 2012).