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Velocity storage mechanism in zebrafish larvae
Author(s) -
Chen ChienCheng,
Bockisch Christopher J.,
Bertolini Giovanni,
Olasagasti Itsaso,
Neuhauss Stephan C. F.,
Weber Konrad P.,
Straumann Dominik,
YingYu Huang Melody
Publication year - 2014
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2013.258640
Subject(s) - optokinetic reflex , vestibular system , zebrafish , reflex , eye movement , vestibulo–ocular reflex , mechanism (biology) , neuroscience , semicircular canal , biology , physics , anatomy , biochemistry , quantum mechanics , gene
Key points• Five‐day‐old zebrafish larvae already exhibit a velocity storage mechanism (VSM). • The VSM in zebrafish larvae emerges earlier than a functional horizontal angular vestibular reflex. • The VSM may be critical to ocular motor control in larval zebrafish.Abstract The optokinetic reflex (OKR) and the angular vestibulo‐ocular reflex (aVOR) complement each other to stabilize images on the retina despite self‐ or world motion, a joint mechanism that is critical for effective vision. It is currently hypothesized that signals from both systems integrate, in a mathematical sense, in a network of neurons operating as a velocity storage mechanism (VSM). When exposed to a rotating visual surround, subjects display the OKR, slow following eye movements frequently interrupted by fast resetting eye movements. Subsequent to light‐off during optokinetic stimulation, eye movements do not stop abruptly, but decay slowly, a phenomenon referred to as the optokinetic after‐response (OKAR). The OKAR is most likely generated by the VSM. In this study, we observed the OKAR in developing larval zebrafish before the horizontal aVOR emerged. Our results suggest that the VSM develops prior to and without the need for a functional aVOR. It may be critical to ocular motor control in early development as it increases the efficiency of the OKR.