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TRPV3: time to decipher a poorly understood family member!
Author(s) -
Nilius Bernd,
Bíró Tamás,
Owsianik Grzegorz
Publication year - 2014
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2013.255968
Subject(s) - transient receptor potential channel , trpv , genodermatosis , subfamily , function (biology) , medicine , biology , microbiology and biotechnology , receptor , neuroscience , genetics , trpv1 , gene
The vanilloid transient receptor potential channel TRPV3 differs in several aspects from other members of the TRPV subfamily. This Ca 2+ ‐, ATP‐ and calmodulin‐regulated channel constitutes a target for many natural compounds and has a unique expression pattern as the most prominent and important TRP channel in keratinocytes of the skin. Although TRPV3 is considered as a thermosensitive channel, its function as a thermosensor in the skin is challenged. Nevertheless, it plays important roles in other skin functions such as cutaneous sensations, hair development and barrier function. More recently, mutations in TRPV3 were linked with a rare genodermatosis known as the Olmsted syndrome. This review gives an overview on properties of TRPV3 and its functions in the skin and skin diseases.