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Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men
Author(s) -
ChurchwardVenne Tyler A.,
Burd Nicholas A.,
Mitchell Cameron J.,
West Daniel W. D.,
Philp Andrew,
Marcotte George R.,
Baker Steven K.,
Baar Keith,
Phillips Stuart M.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2012.228833
Subject(s) - leucine , anabolism , whey protein , amino acid , myofibril , chemistry , protein biosynthesis , endocrinology , medicine , sarcopenia , protein catabolism , resistance training , biochemistry , biology
Key points• Essential amino acids (EAAs) stimulate increased rates of myofibrillar protein synthesis (MPS). • Leucine is a key regulator of MPS in rodents; however, its importance relative to the other EAAs is not clear. • About 20 g of protein maximally stimulates MPS after resistance exercise in young men, but we do not know if smaller doses can be made better by adding certain amino acids. • We report that a suboptimal dose of whey protein (6.25 g) supplemented with either leucine or a mixture of EAAs without leucine stimulates MPS similar to 25 g of whey protein under resting conditions; however, only 25 g of whey sustains exercise‐induced rates of MPS. • Adding leucine or a mixture of EAAs without leucine to a suboptimal dose of whey is as effective as 25 g whey at stimulating fed rates of MPS; however, 25 g of whey is better suited to increase resistance exercise‐induced muscle anabolism.