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Expression of gastrin‐releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility
Author(s) -
Tattersall Mark,
Cordeaux Yolande,
CharnockJones D. Stephen,
Smith Gordon C. S.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2012.228239
Subject(s) - contractility , myometrium , endocrinology , receptor , medicine , gastrin releasing peptide , incubation , preterm labor , uterus , chemistry , biology , neuropeptide , pregnancy , fetus , bombesin , biochemistry , genetics
Key points • Increased uterine stretch appears to increase the risk of preterm labour, but the mechanism by which this might occur is unknown. • Gastrin‐releasing peptide (GRP) mRNA levels are increased by stretch of myometrial explants and incubation of stretched explants in GRP antagonists can decrease their contractility. • GRP may be a target for novel therapies to decrease the risk of preterm labour in women with multiple pregnancies.