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Ca 2+ ‐stimulated adenylyl cyclases regulate the L‐type Ca 2+ current in guinea‐pig atrial myocytes
Author(s) -
Collins Thomas P.,
Terrar Derek A.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.227066
Subject(s) - adenylyl cyclase , myocyte , intracellular , medicine , chemistry , stimulation , endocrinology , atrial myocytes , compartmentalization (fire protection) , enzyme , biology , biochemistry
Key points • Adenylyl cyclases (ACs), the enzymes that synthesize cAMP, are essential for the inotropic response of cardiac muscle to adrenergic stimulation. • Ca 2+ ‐stimulated isoforms of AC have previously been identified in the sino‐atrial node of the heart, where they contribute to pacemaking. • In this study, we demonstrate that Ca 2+ ‐stimulated isoforms of AC regulate the L‐type Ca 2+ current in atrial myocytes. • This regulation of the L‐type Ca 2+ current provides a feedback mechanism for the Ca 2+ released from intracellular stores to control Ca 2+ entry to atrial myocytes. • These Ca 2+ ‐stimulated ACs may be significant for the compartmentalization of cAMP signalling in atrial myocytes.