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Regulation of glucose and glycogen metabolism during and after exercise
Author(s) -
Jensen Thomas E.,
Richter Erik A.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.224972
Subject(s) - glycogen , glycogen phosphorylase , glycogen synthase , medicine , endocrinology , chemistry , carbohydrate metabolism , glycogen branching enzyme , phosphorylase kinase , glycogen debranching enzyme
Abstract Utilization of carbohydrate in the form of intramuscular glycogen stores and glucose delivered from plasma becomes an increasingly important energy substrate to the working muscle with increasing exercise intensity. This review gives an update on the molecular signals by which glucose transport is increased in the contracting muscle followed by a discussion of glycogen mobilization and synthesis by the action of glycogen phosphorylase and glycogen synthase, respectively. Finally, this review deals with the signalling relaying the well‐described increased sensitivity of glucose transport to insulin in the post‐exercise period which can result in an overshoot of intramuscular glycogen resynthesis post exercise (glycogen supercompensation).