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P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit
Author(s) -
Hwang Sung Jin,
Blair Peter J.,
Durnin Leonie,
MutafovaYambolieva Violeta,
Sanders Kenton M.,
Ward Sean M.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.224634
Subject(s) - inhibitory postsynaptic potential , neuroscience , chemistry , inhibitory control , biology , cognition
Key points • Normal colonic motility is regulated by excitatory and inhibitory motor neurons, and previous studies have shown that both components of neural regulation are important for normal propulsion of colonic contents. • Inhibitory neural control consists of two main components, and the major neurotransmitters have been identified as nitric oxide and purines; we investigated the nature of the receptors responsible for purine inhibitory motor control of the colon using mice with P2Y1 receptors deactivated. • Inhibitory control of the colon by purine neurotransmitters was dramatically decreased in these animals and transit of fecal pellets was delayed. • Inhibitory responses to purine neurotransmission and exogenous β‐NAD, a neurotransmitter candidate, were completely abolished in P2Y1 receptor knockouts. • These studies demonstrate the importance of purinergic neural regulation of colonic motility and suggest this form of neural regulation depends upon P2Y1 receptors to receive and transduce inhibitory neural signals.