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Acute stress induces down‐regulation of large‐conductance Ca 2+ ‐activated potassium channels in the lateral amygdala
Author(s) -
Guo Yanyan,
Liu Shuibing,
Cui GuangBin,
Ma Lan,
Feng Bin,
Xing Jianghao,
Yang Qi,
Li Xiaoqiang,
Wu Yumei,
Xiong Lize,
Zhang Weiqi,
Zhao Minggao
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.223784
Subject(s) - amygdala , anxiety , potassium channel , neuroscience , potassium , psychology , depression (economics) , chemistry , medicine , psychiatry , organic chemistry , economics , macroeconomics
Key points• Stress can lead to the development of behavioural disorders associated with cognitive impairments, depression and anxiety. • Large‐conductance Ca 2+ ‐activated potassium channels (BKCa) are highly expressed in the brain. Here we found that acute stress induced a significant reduction in BKCa channel expression in the amygdala of mice, which accompanied anxiety‐like behaviours. • Activation of BKCa channels in the amygdala could reverse the stress‐induced anxiety‐like behaviours. This research may help us understand the underlying mechanisms of anxiety‐like behaviour induced by acute stress.