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The omega‐6 fatty acid derivative 15‐deoxy‐Δ 12,14 ‐prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress
Author(s) -
Abdo Hind,
Mahé Maxime M.,
Derkinderen Pascal,
BachNgohou Kalyane,
Neunlist Michel,
Lardeux Bernard
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.222935
Subject(s) - neuroprotection , enteric nervous system , glutathione , neurotoxicity , biochemistry , pharmacology , astrocyte , prostaglandin , chemistry , biology , microbiology and biotechnology , enzyme , endocrinology , toxicity , central nervous system , organic chemistry
Key points• Enteric glial cells play a major role in the regulation of enteric neuronal functions. • 15‐Deoxy‐Δ 12,14 ‐prostaglandin J2 (15d‐PGJ2) is an omega‐6 fatty acid derivative that was recently identified as a novel glial‐derived mediator involved in the control of the proliferation and differentiation of intestinal epithelial cells. • In this study, we show that 15d‐PGJ2 has neuroprotective properties during oxidative stress in the enteric nervous system. • We furthermore show that 15d‐PGJ2 neuroprotective effects are dependent on the activation of the Nrf2 pathway and are associated with an increase of glutathione synthesis in neurons. • This study supports the concept that omega‐6 derivatives might be used in preventive and/or therapeutic strategies for the treatment of enteric neuropathies.