The omega‐6 fatty acid derivative 15‐deoxy‐Δ 12,14 ‐prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress

Key points•  Enteric glial cells play a major role in the regulation of enteric neuronal functions. •  15‐Deoxy‐Δ 12,14 ‐prostaglandin J2 (15d‐PGJ2) is an omega‐6 fatty acid derivative that was recently identified as a novel glial‐derived mediator involved in the control of the proliferation and differentiation of intestinal epithelial cells. •  In this study, we show that 15d‐PGJ2 has neuroprotective properties during oxidative stress in the enteric nervous system. •  We furthermore show that 15d‐PGJ2 neuroprotective effects are dependent on the activation of the Nrf2 pathway and are associated with an increase of glutathione synthesis in neurons. •  This study supports the concept that omega‐6 derivatives might be used in preventive and/or therapeutic strategies for the treatment of enteric neuropathies.