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Pivotal role of mitochondrial Na + –Ca 2+ exchange in antigen receptor mediated Ca 2+ signalling in DT40 and A20 B lymphocytes
Author(s) -
Kim Bongju,
Takeuchi Ayako,
Koga Orie,
Hikida Masaki,
Matsuoka Satoshi
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.222927
Subject(s) - endoplasmic reticulum , organelle , mitochondrion , cytoplasm , antigen , receptor , microbiology and biotechnology , chemistry , lymphocyte , biology , biophysics , biochemistry , immunology
Non‐technical summary Elevation of cytoplasmic Ca 2+ is one of the early responses of lymphocytes upon the antigen recognition by the surface receptor. We show here that the Ca 2+ response is maintained by Ca 2+ transfer from mitochondria to endoplasmic reticulum through mitochondrial Na + –Ca 2+ exchange. The result helps us understanding how lymphocyte responses to antigen are organized at organelle level.