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Sound‐evoked network calcium transients in mouse auditory cortex in vivo
Author(s) -
Grienberger Christine,
Adelsberger Helmuth,
Stroh Albrecht,
Milos RuxandraIulia,
Garaschuk Olga,
Schierloh Anja,
Nelken Israel,
Konnerth Arthur
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.222513
Subject(s) - auditory cortex , in vivo , neuroscience , sound (geography) , calcium , cortex (anatomy) , chemistry , biology , physics , acoustics , medicine , microbiology and biotechnology
Non‐technical summary The coherent activity of a large number of neurons forming functional cell assemblies crucially contributes to neuronal information processing in the brain. It is believed that activity of such populations constitutes a key mechanism linking awareness, stimuli from the external world, memory and behaviour. In this study, we recorded population calcium signals in the auditory cortex of mice using an optical fibre. We found that the population activity was dominated by transients lasting ∼1 s. These calcium transients directly reflected the action potential firing of local clusters of neurons and occurred spontaneously as well as in response to sound stimulation. We characterized in detail the spontaneous and sound‐evoked calcium signals and the relation between the two. Thus, we were able to identify population calcium transients as an important element of sensory signalling.