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Diet‐induced adaptation of vagal afferent function
Author(s) -
Kentish Stephen,
Li Hui,
Philp Lisa K.,
O’Donnell Tracey A.,
Isaacs Nicole J.,
Young Richard L.,
Wittert Gary A.,
Blackshaw L. Ashley,
Page Amanda J.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.222158
Subject(s) - ghrelin , endocrinology , nodose ganglion , medicine , orexigenic , receptor , vagus nerve , cholecystokinin , gastric distension , distension , biology , stimulation , neuropeptide , neuropeptide y receptor
Non‐technical summary Obesity is the result of a disruption in the maintenance of energy balance such that energy intake exceeds expenditure. Why this occurs is unknown. We show that after food deprivation or consumption of a high fat diet gastric vagal afferent responses to distension are reduced. In addition, the effect of the orexigenic peptide ghrelin is enhanced. Thus the satiety signal is reduced not only after food deprivation but also after a high fat diet. This reduction in satiety signalling may explain the increase in energy intake and disruption in maintenance of energy balance in obesity.