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Function and expression of ryanodine receptors and inositol 1,4,5‐trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles
Author(s) -
Westcott Erika B.,
Goodwin Erica L.,
Segal Steven S.,
Jackson William F.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.222083
Subject(s) - ryanodine receptor , calcium , receptor , medicine , endocrinology , vascular smooth muscle , calcium signaling , vasomotor , inositol , calcium in biology , inositol trisphosphate , voltage dependent calcium channel , chemistry , myocyte , biology , microbiology and biotechnology , anatomy , smooth muscle
Key points • Feed arteries and arterioles, respectively, control the magnitude and distribution of blood flow to skeletal muscle but regional differences in the regulation of vasomotor tone are poorly understood. • To provide this insight, we investigated functional roles and molecular expression of the calcium‐release channels, ryanodine receptors (RyRs) and inositol 1,4,5‐trisphosphate receptors (IP 3 Rs) in smooth muscle cells (SMCs) of isolated pressurized vessels of mice. • In feed arteries, SMCs displayed localized calcium sparks and more global calcium waves. In arterioles, SMCs exhibited only calcium waves. • Calcium signalling and vasomotor tone were governed by both RyRs and IP 3 Rs in feed arteries, while only IP 3 Rs were functional in arterioles. Regional differences were also manifest in the expression profile of RyR isoforms. • This new perspective offers the potential for developing novel strategies to target therapeutic interventions to selective regions of vascular beds.