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Acid‐sensing ion channel subtype 3 function and immunolabelling increases in skeletal muscle sensory neurons following femoral artery occlusion
Author(s) -
Xing Jihong,
Lu Jian,
Li Jianhua
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.221788
Subject(s) - acid sensing ion channel , dorsal root ganglion , hindlimb , sensory system , medicine , anatomy , sensory neuron , chemistry , neuroscience , endocrinology , ion channel , biology , receptor
Non‐technical summary Limb ischaemia commonly occurs in peripheral artery disease and blood pressure response to stimulation of muscle afferent nerves during exercise activity is augmented in this disease; however, the mechanisms responsible for this physiological process are not well‐known. In this report, expression and function of acid‐sensing ion channels subtype 3 (ASIC 3 ) in muscle afferent nerves were examined following the hindlimb ischaemia induced by femoral artery occlusion. The data provided here suggest that femoral artery occlusion increases ASIC 3 expression and responsiveness in muscle sensory neurons. The results help us better understand why the blood pressure response to exercise is exaggerated in patients with peripheral artery disease.