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The Mother of All Battles 20 years on: is LTP expressed pre‐ or postsynaptically?
Author(s) -
Kullmann Dimitri M.
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.221127
Subject(s) - postsynaptic potential , long term potentiation , neuroscience , nmda receptor , postsynaptic density , glutamate receptor , chemistry , receptor , biology , biochemistry
The early 1990s saw an intense debate over the locus of expression of NMDA receptor‐dependent LTP. This provided an impetus for intense research into the mechanisms of modulation and trafficking of glutamate receptors and presynaptic vesicles. As new forms of LTP are discovered at different synapses, a simple resolution of the pre‐ versus postsynaptic debate seems increasingly remote.