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Action potential‐triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices
Author(s) -
Zhang Bo,
Zhang XiaoYu,
Luo PiFu,
Huang Wei,
Zhu FeiPeng,
Liu Tao,
Du YiRu,
Wu QiHui,
Lü Jin,
Xiu Yun,
Liu LiNa,
Huang HongPing,
Guo Shu,
Zheng Hui,
Zhang Claire Xi,
Zhou Zhuan
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.221051
Subject(s) - exocytosis , depolarization , postsynaptic potential , neuroscience , somatic cell , axon , membrane potential , secretion , chemistry , biology , microbiology and biotechnology , biophysics , endocrinology , biochemistry , receptor , gene
Non‐technical summary Ca 2+ ‐regulated axon terminal exocytosis is essential for neuronal communication in the CNS. Besides, the somata may also undergo Ca 2+ ‐dependent exocytosis in some neurons in the brain. In the present work we recorded activity/Ca 2+ ‐dependent secretion in somata of the mesencephalic trigeminal nucleus (MeV). Following nerve activity, somatic secretion signals are recorded as changes in membrane surface area, as measured by the membrane capacitance. The depolarization‐induced somatic exocytosis correlates with transient reduction in the GABA‐mediated postsynaptic currents. These results implicated that the somatic secretion may play a role in bidirectional communication between pre‐ and post‐connected neurons in the sensory MeV brain slice neurons.