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Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry
Author(s) -
Wang Kai,
Terrenoire Cecile,
Sampson Kevin J.,
Iyer Vivek,
Osteen Jeremiah D.,
Lu Jonathan,
Keller Gordon,
Kotton Darrell N.,
Kass Robert S.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.220863
Subject(s) - induced pluripotent stem cell , embryonic stem cell , myocyte , potassium channel , protein subunit , microbiology and biotechnology , biology , ion channel , transfection , electrophysiology , hek 293 cells , context (archaeology) , cell culture , neuroscience , gene , biophysics , biochemistry , genetics , paleontology , receptor
Non‐technical summary The human heart is a pump that works only when its internal electrical system coordinates both its filling and its capacity to eject blood. This critical electrical timing is coordinated by many different ion channels, and this study looks at the one known as I Ks . Mutations in its α subunit, KCNQ1, constitute the majority of cases of the disorder long QT syndrome (LQT‐1). Here we have examined properties of human cardiac cells during very early stages of development and found evidence for the manner in which the subunits of I Ks assemble; our data suggest that this assembly may be flexible and may change during development and/or disease.