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Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells
Author(s) -
Street Jonathan M.,
Birkhoff Willem,
Menzies Robert I.,
Webb David J.,
Bailey Matthew A.,
Dear James W.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.220277
Subject(s) - microvesicles , aquaporin 2 , exosome , microbiology and biotechnology , kidney , desmopressin , chemistry , nanoparticle tracking analysis , biology , endocrinology , microrna , biochemistry , water channel , mechanical engineering , engineering , inlet , gene
Non‐technical summary Like most cells, those of the kidney release protein and RNA in structures called exosomes. It is possible that the contents of exosomes released into the urine from one part of the kidney can alter the function of downstream cells. We have used a cell model to test whether exosomes act as cell‐to‐cell messengers within the kidney. First, cells were exposed to a hormone that regulates the body's retention of water. This increased the levels of water channels within the cells and also within their exosomes. Next, these exosomes were placed onto a separate batch of cells, which responded by increasing their transport of water. This study shows that exosomes are a new mechanism for the transfer of physiological information within the kidney.