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Effect of muscle metaboreflex activation on spontaneous cardiac baroreflex sensitivity during exercise in humans
Author(s) -
Hartwich Doreen,
Dear William E.,
Waterfall Jessica L.,
Fisher James P.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.219964
Subject(s) - baroreflex , heart rate , blood pressure , medicine , stimulation , cardiology
Non‐technical summary The ‘arterial baroreflex’ plays an important role in the moment‐to‐moment regulation of blood pressure. It does this partly by eliciting changes in heart rate, but its ability to do this (i.e. sensitivity) during exercise is reduced from rest. During exercise, chemicals accumulate in the muscles (i.e. metabolites) that stimulate sensory nerves within the muscle (i.e. muscle metaboreflex). We show for the first time in humans that the stimulation of metabolically sensitive nerves within the muscles during leg cycling exercise decreases arterial baroreflex sensitivity. This new knowledge increases our understanding of the control of the human heart during exercise.