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The role of skeletal muscle mTOR in the regulation of mechanical load‐induced growth
Author(s) -
Goodman Craig A.,
Frey John W.,
Mabrey Danielle M.,
Jacobs Brittany L.,
Lincoln Hannah C.,
You JaeSung,
Hornberger Troy A.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.218255
Subject(s) - pi3k/akt/mtor pathway , rptor , skeletal muscle , mechanistic target of rapamycin , sirolimus , microbiology and biotechnology , protein kinase b , kinase , phosphorylation , mtorc2 , chemistry , biology , cancer research , mtorc1 , signal transduction , endocrinology , biochemistry
Non‐Technical Summary Chronic mechanical loading (CML) of skeletal muscle induces growth and this effect can be blocked by the drug rapamycin. Rapamycin is considered to be a highly specific inhibitor of the mammalian target of rapamycin (mTOR), and thus, many have concluded that mTOR plays a key role in CML‐induced growth. However, direct evidence that mTOR confers the CML‐induced activation of growth promoting events such as hypertrophy, hyperplasia and ribosome biogenesis is lacking. This study addressed that gap in knowledge by using a specialized line of transgenic mice. Surprisingly, the results indicate that only a few of the growth promoting events induced by CML are fully dependent on mTOR signalling (e.g. hypertrophy). These results advance our understanding of the molecular mechanisms that regulate skeletal muscle mass and should help future studies aimed at identifying targets for therapies that can prevent the loss of muscle mass during conditions such as bedrest, immobilization, and ageing.