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Brain glycogen supercompensation following exhaustive exercise
Author(s) -
Matsui Takashi,
Ishikawa Taro,
Ito Hitoshi,
Okamoto Masahiro,
Inoue Koshiro,
Lee Minchul,
Fujikawa Takahiko,
Ichitani Yukio,
Kawanaka Kentaro,
Soya Hideaki
Publication year - 2012
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.217919
Subject(s) - glycogen , skeletal muscle , basal (medicine) , medicine , hippocampus , endocrinology , physical exercise , exercise physiology , neuroscience , biology , physical medicine and rehabilitation , diabetes mellitus
Non‐technical summary Exercise training elicits an increase in the basal level of muscular glycogen. This happens when glycogen recovers to above its basal level (supercompensation) after it decreases with acute exercise. Although untested, it is hypothesized that, similar to that of skeletal muscle, brain glycogen supercompensation occurs after acute exhaustive exercise. We provide evidence that exhaustive exercise induces glycogen supercompensation not only in skeletal muscles, but also in the brain. Furthermore, we observed exercise training‐induced increases in basal glycogen levels in the cortex and hippocampus, which are involved in motor control and cognitive function. This suggests that, like skeletal muscles, the brain adapts metabolically, probably to meet the increased energy demands of exercise training.