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Purinergic signalling mobilizes mitochondrial Ca 2+ in mouse Sertoli cells
Author(s) -
Veitinger Sophie,
Veitinger Thomas,
Cainarca Silvia,
Fluegge Daniela,
Engelhardt Corinna H.,
Lohmer Stefan,
Hatt Hanns,
Corazza Sabrina,
Spehr Jennifer,
Neuhaus Eva M.,
Spehr Marc
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.216309
Subject(s) - sertoli cell , purinergic receptor , microbiology and biotechnology , purinergic signalling , mitochondrion , chemistry , biology , endocrinology , biochemistry , extracellular , spermatogenesis , adenosine receptor , receptor , agonist
Non‐Technical Summary In mammalian testes, Sertoli cells play a key physiological role in germ cell development. Previous research has implicated local ATP release as a potential mechanism of Sertoli cell stimulation. We show that, in mouse Sertoli cells, two different receptor proteins are activated by ATP. Receptor activation, in turn, causes elevation of calcium ion levels inside the cells. By using a novel method to visualize such calcium signals, we identify mitochondria as essential elements of calcium regulation in the testis.