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Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats
Author(s) -
Larson Jeffrey A.,
Ogagan P. Dafe,
Chen Guoqing,
Shen Bing,
Wang Jicheng,
Roppolo James R.,
de Groat William C.,
Tai Changfeng
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.215657
Subject(s) - urinary bladder , overactive bladder , saline , urination , chemistry , metabotropic glutamate receptor , antagonist , metabotropic glutamate receptor 5 , endocrinology , isovolumetric contraction , medicine , stimulation , pharmacology , glutamate receptor , receptor , urinary system , pathology , alternative medicine , blood pressure , diastole
Non‐technical summary Lower urinary tract disorders including painful and overactive bladder conditions are very difficult to treat. Neuromodulation which is one of the successful therapies for lower urinary tract disorders, stimulates afferent nerves to modulate the neural pathway and achieve a therapeutic effect. We show that the metabotropic glutamate receptor 5 is activated in the central nervous system during pudendal neuromodulation. Understanding the neurotransmitter mechanisms involved in neuromodulation therapy may promote the development of new pharmacological treatments or improve the clinical outcome by combining neuromodulation with pharmacological therapy.