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Prior endurance exercise prevents postprandial lipaemia‐induced increases in reactive oxygen species in circulating CD31 + cells
Author(s) -
Jenkins Nathan T.,
Landers Rian Q.,
Thakkar Sunny R.,
Fan Xiaoxuan,
Brown Michael D.,
Prior Steven J.,
Spangenburg Espen E.,
Hagberg James M.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.215277
Subject(s) - postprandial , cd31 , reactive oxygen species , oxidative stress , endothelium , medicine , endocrinology , meal , nitric oxide , endothelial dysfunction , chemistry , cell function , physical exercise , cell , angiogenesis , biochemistry , insulin
Non‐Technical Summary Circulating angiogenic cells (CACs) repair and maintain the vascular endothelium. CACs are responsive to lifestyle factors such as diet and physical activity. For example, their capacity to regenerate the endothelium is impaired in cardiovascular disease patients, whereas exercise training can improve CAC function. In this study, we examined the effects of a high‐fat meal with and without prior endurance exercise on several molecular aspects of CAC function, including levels of reactive oxygen species (ROS), nitric oxide (NO), intracellular lipids, and gene expression. Our results indicated that the high‐fat meal induced significant oxidative stress (i.e. ROS production) in the CACs that expressed the cell surface protein CD31. However, when subjects performed a single bout of exercise on the prior day, the meal had no effect on ROS in CD31 + cells. Therefore, we concluded that prior exercise prevents the oxidative stress induced by a high‐fat meal in CD31 + CACs.