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The potassium–chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport‐independent mechanism
Author(s) -
Wei WeiChun,
Akerman Colin J.,
Newey Sarah E.,
Pan Jiliu,
Clinch Nicholas W. V.,
Jacob Yves,
Shen MengRu,
Wilkins Robert J.,
Ellory J. Clive
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.214635
Subject(s) - gene knockdown , cotransporter , cell migration , microbiology and biotechnology , chemistry , cell , intracellular , cell growth , cell culture , biology , apoptosis , biochemistry , sodium , genetics , organic chemistry
Non‐Technical Summary K + –Cl − cotransporters (KCCs) play a fundamental role in epithelial cell function, both in the context of ionic homeostasis and also in cell morphology, cell division and locomotion. Unlike other ubiquitously expressed KCC isoforms, expression of KCC2 is widely considered to be restricted to neurons. Here we report a novel finding that KCC2 is widely expressed in several human cancer cell lines including the cervical cancer cell line (SiHa). Our data establish that KCC2 expression and function is not restricted to neurons and that KCC2 serves to increase cervical cancer progression via an ion transport‐independent mechanism.