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Twelve weeks of treadmill exercise does not alter age‐dependent chronic kidney disease in the Fisher 344 male rat
Author(s) -
Moningka Natasha C.,
Sindler Amy L.,
MullerDelp Judy M.,
Baylis Chris
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.214569
Subject(s) - kidney disease , treadmill , medicine , disease , kidney , physiology , endocrinology , cardiology
Non‐technical summary In older people, the function of the kidney deteriorates, and one possible way to slow this process down is through exercise. Exercise increases the abundance of important enzymes that are needed for optimal vessel health and kidney function, for instance the nitric oxide synthase and superoxide dismutase (SOD) enzymes. It also reduces oxidative stress, a type of cellular injury caused by highly reactive molecules. When we compared young and old sedentary rats to young and old exercise‐trained (12 weeks treadmill) rats, we found that exercise was not effective in reversing the age‐related kidney changes. In old rats, renal function declined as did the abundance of the protective SOD enzymes, and oxidative stress increased; interestingly, exercise did not influence these changes. Our results suggest that the cardiovascular benefits of exercise do not necessarily extend to the kidney.