Premium
n –3 polyunsaturated fatty acids in the maternal diet modify the postnatal development of nervous regulation of intestinal permeability in piglets
Author(s) -
De Quelen F.,
Chevalier J.,
RolliDerkinderen M.,
Mourot J.,
Neunlist M.,
Boudry G.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.214056
Subject(s) - intestinal permeability , lactation , polyunsaturated fatty acid , endocrinology , fatty acid , central nervous system , medicine , enteric nervous system , fetus , pregnancy , nervous system , biology , chemistry , biochemistry , neuroscience , genetics
Non‐technical summary In this study, we demonstrated that supplementation of the maternal diet with a particular fatty acid, 18:3 n‐3, the precursor of the n‐3 fatty acid family, modified intestinal permeability, probably via diet‐induced neuroplastic changes of the enteric nervous system of newborn piglets. These findings suggest that feeding fatty acids of the n‐3 family during pregnancy and lactation impact newborn intestinal barrier function. However, the beneficial versus harmful consequences of this increased intestinal permeability remain to be elucidated.