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Paradoxical effects of streptozotocin‐induced diabetes on endothelial dysfunction in stroke‐prone spontaneously hypertensive rats
Author(s) -
Zhong MeiFang,
Shen WeiLi,
Wang Jian,
Yang Jie,
Yuan WenJun,
He Jin,
Wu PingPing,
Wang Yuan,
Zhang Lan,
Higashino Hideaki,
Chen Hong
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.213686
Subject(s) - diabetes mellitus , medicine , blood pressure , stroke (engine) , cardiology , endothelial dysfunction , streptozotocin , type 2 diabetes , disease , endocrinology , blood vessel , mechanical engineering , engineering
Non‐Technical Summary Elevated blood glucose is generally regarded as one of the risk factors that lead to coronary heart disease in patients with type 2 diabetes. However, our studies show that after inducing short‐term damage, high blood glucose subsequently provides paradoxical protection for vessel function of animals with high blood pressure. Vessels can adapt to sustained high blood glucose and produce different stress proteins to counteract, to some extent, the damage brought about by hypertension. The results help us understand part of the basis for vessel adaptation in diabetes. The implication for treatment of diabetes is that if the patients have long‐standing diabetes and established cardiovascular disease, the target of blood glucose lowering should be less stringent and reached gradually to avoid abrupt cancellation of the pre‐existing adaptations.