Premium
Cross‐reactivity of acid‐sensing ion channel and Na + –H + exchanger antagonists with nicotinic acetylcholine receptors
Author(s) -
SantosTorres Julio,
Ślimak Marta A.,
Auer Sebastian,
IbañezTallon Inés
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.213272
Subject(s) - nicotinic agonist , amiloride , chemistry , receptor , pharmacology , population , diuretic , ion channel , potassium , acetylcholine receptor , endocrinology , medicine , biochemistry , sodium , organic chemistry , environmental health
Non‐Technical Summary Cardiovascular disease and high blood pressure (hypertension) are frequent in the human population. Amiloride is commonly given as a diuretic to reduce hypertension without eliminating potassium, while zoniporide is used to aid in recovery after cardiac failure. We show here that high concentrations of these drugs have additional effects on nicotinic receptors that are present in the brain and body. The possibility that these drugs could affect nicotinic receptors when given as medications should be further investigated.