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Enhanced high‐frequency membrane potential fluctuations control spike output in striatal fast‐spiking interneurones in vivo
Author(s) -
Schulz Jan M.,
Pitcher Toni L.,
Savanthrapadian Shakuntala,
Wickens Jeffery R.,
Oswald Manfred J.,
Reynolds John N. J.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.212944
Subject(s) - neuroscience , striatum , electrophysiology , biology , neurotransmission , receptor , dopamine , biochemistry
Non‐technical summary Rhythmic activity patterns are a common theme throughout neuroscience. However, it is still poorly understood how network functions are modulated by fast oscillatory inputs from distant brain regions. In this respect, the striatum is particularly interesting as almost all neuronal activity is driven by long‐range inputs. We find that the three main classes of neurones in the striatum show very distinct oscillatory activity patterns in specific frequency ranges. In particular, we show that fast‐spiking interneurones are highly sensitive to fast fluctuating synaptic inputs in the intact brain. This sensitivity was probably due to a combination of faster dynamics of synaptic inputs and intrinsic amplification of high‐frequency signals. In contrast, projection neurones and other interneurones lacking these mechanisms were insensitive to fast oscillatory input patterns. These results suggest that transmission of fast cortical oscillatory inputs modulates information processing in the striatum via engagement of fast‐spiking interneurones.