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SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans
Author(s) -
Donato Anthony J.,
Magerko Katherine A.,
Lawson Brooke R.,
Durrant Jessica R.,
Lesniewski Lisa A.,
Seals Douglas R.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.211219
Subject(s) - enos , endothelial dysfunction , ageing , medicine , sirtuin 1 , endocrinology , endothelium , nitric oxide , sodium nitroprusside , nitric oxide synthase type iii , nitric oxide synthase , chemistry , downregulation and upregulation , biochemistry , gene
Non‐technical summary Advancing age is a major risk factor for the development of cardiovascular disease. A key characteristic of older arteries that may lead to cardiovascular disease is reduced endothelial function, characterized by blunted endothelium‐dependent dilatation. Sirtuins, specifically sirtuin‐1, are proteins linked to increases in lifespan and lower incidence of age‐related diseases. We hypothesized that diminished sirtuin‐1 with advancing age may alter regulation of a key endothelium dilatory enzyme, nitric oxide synthase. Our findings provide novel translational evidence that sirtuin‐1 expression and activity contribute to arterial endothelial dysfunction with ageing and that this may be due to altered nitric oxide synthase activation. Importantly, our results provide further compelling support for sirtuin‐1 as a potential therapeutic target for lifestyle and pharmacological interventions aimed at the prevention and treatment of arterial ageing and age‐associated cardiovascular diseases.