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Respiratory modulation of muscle sympathetic nerve activity is not increased in essential hypertension or chronic obstructive pulmonary disease
Author(s) -
Fatouleh Rania,
Macefield Vaughan G.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.210534
Subject(s) - copd , medicine , respiratory system , blood pressure , pulmonary disease , cardiology , sympathetic nervous system , pulmonary hypertension , respiration , sympathetic activity , disease , skeletal muscle , endocrinology , heart rate , anatomy
Non‐Technical Summary High blood pressure is known to be caused by an increase in activity of the sympathetic nerves that constrict blood vessels in skeletal muscle and the gut. Experiments in the spontaneous hypertensive rat (SHR) suggest that the hypertension is brought about by an increase in coupling between respiration and sympathetic outflow. We tested whether this mechanism occurs in two models of elevated muscle sympathetic nerve activity (MSNA) in human subjects: essential hypertension (HT) and chronic obstructive pulmonary disease (COPD). Unlike the SHR model, respiratory modulation of MSNA was not increased in either HT or COPD. These results help us understand how the cardiovascular and respiratory systems interact in health and disease.