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Inhibition of K + secretion in the distal nephron in nephrotic syndrome: possible role of albuminuria
Author(s) -
Fila Marc,
Brideau Gaëlle,
Morla Luciana,
Cheval Lydie,
Deschênes Georges,
Doucet Alain
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.209692
Subject(s) - nephrotic syndrome , potassium , endocrinology , albuminuria , medicine , nephron , sodium , secretion , chemistry , hyperkalemia , kidney , organic chemistry
Non‐technical summary Plasma potassium concentration is a major determinant of muscle contractility and nerve conduction. The maintenance of plasma potassium concentration depends on the ability of kidneys to daily secrete in the urine the exact quantity of potassium ingested in the food. We show that in nephrotic syndrome, a common disease featuring abnormal urinary protein excretion and sodium retention, the membrane protein called ROMK channel responsible for kidney potassium secretion is inhibited. Thus, nephrotic rats are unable to excrete a dietary load of potassium and develop hyperkalaemia. Based on these findings, we would recommend not only a low sodium diet but also a controlled potassium diet for patients with nephrotic syndrome.