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Protective effect of caspase inhibition on compression‐induced muscle damage
Author(s) -
Teng Bee T.,
Tam Eric W.,
Benzie Iris F.,
Siu Parco M.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.209619
Subject(s) - medicine , pressure sores , wheelchair , physical medicine and rehabilitation , intensive care medicine , surgery , world wide web , computer science
Non‐technical summary A pressure ulcer, also known as a pressure sore, bedsore or decubitus ulcer, results from localized ulcerated tissue breakdown caused by sustained, unrelieved mechanical pressure in the body–support interface such as with a bed, wheelchair and orthoses/prostheses. Pressure ulcers are common in the wheelchair bound or bedridden frail elderly patients with neuromuscular disorder and orthoses/prostheses clients. Pressure ulcers represent a significant health problem as they impose a heavy burden on sufferers, with negative psychological, physical, social and financial consequences. Most importantly, there are currently no effective therapies for preventing and treating pressure ulcers. In the present study, our data demonstrate that pharmacological inhibition of caspase is effective in alleviating muscle damage induced by prolonged moderate compression. These findings suggest that regimens targeting caspase/apoptosis inhibition might be of use to prevent or treat pressure ulcers.