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Augmented skeletal muscle hyperaemia during hypoxic exercise in humans is blunted by combined inhibition of nitric oxide and vasodilating prostaglandins
Author(s) -
Crecelius Anne R.,
Kirby Brett S.,
Voyles Wyatt F.,
Dinenno Frank A.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.209486
Subject(s) - hyperaemia , vasodilation , medicine , hypoxia (environmental) , brachial artery , nitric oxide , anesthesia , endocrinology , physical exercise , chemistry , cardiology , blood flow , blood pressure , oxygen , organic chemistry
Non‐technical summary Blood flow to muscle increases during exercise in order to deliver more oxygen. When there is less oxygen in the blood, as in systemic hypoxia, blood flow also increases. If exercise occurs during hypoxia, the blood flow response is greater than during normal oxygen conditions, but the mechanisms by which this happens are not clear. We show that two substances that the body produces, nitric oxide and prostaglandins, contribute to this increased blood flow during hypoxic exercise. These results help us better understand how oxygen delivery is regulated and may be especially important for populations which are unable to produce these substances that help increase blood flow.