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Two distinct vesicle pools for depolarization‐induced exocytosis in somata of dorsal root ganglion neurons
Author(s) -
Liu Tao,
Shang ShuJiang,
Liu Bin,
Wang ChangHe,
Wang YeShi,
Xiong Wei,
Zheng LiangHong,
Zhang Claire Xi,
Zhou Zhuan
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.208777
Subject(s) - exocytosis , depolarization , dorsal root ganglion , vesicle , microbiology and biotechnology , neurotransmitter , kiss and run fusion , stimulation , neuroscience , biology , chemistry , biophysics , synaptic vesicle , endocrinology , biochemistry , secretion , membrane , central nervous system , sensory system
Non‐technical summary Ca 2+ ‐regulated exocytosis is essential for neurotransmitter and hormone release. As well as this type of exocytosis, the somata of dorsal root ganglion (DRG) neurons also show Ca 2+ ‐independent but voltage‐dependent exocytosis. It is unclear whether these two types of exocytosis use the same or different vesicle pools in DRG neurons. Here, we found that they were separable in response to the same stimulation in low external Ca 2+ solution. Depletion of the Ca 2+ ‐dependent vesicle pool did not affect the Ca 2+ ‐independent but voltage‐dependent exocytosis. These results show that DRG neurons exhibit two distinct types of exocytosis that use different vesicle pools.