Premium
Direct demonstration of inhibitory interactions between long interval intracortical inhibition and short interval intracortical inhibition
Author(s) -
Ni Zhen,
Gunraj Carolyn,
WagleShukla Aparna,
Udupa Kaviraja,
Mazzella Filomena,
Lozano Andres M.,
Chen Robert
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.207928
Subject(s) - transcranial magnetic stimulation , inhibitory postsynaptic potential , silent period , interstimulus interval , evoked potential , chemistry , neuroscience , stimulation , psychology
Non‐technical summary Motor cortical output is suppressed by two cortical inhibitory systems, short interval intracortical inhibition (SICI) and long interval intracortical inhibition (LICI). SICI is decreased in the presence of LICI. However, there is a long‐standing argument whether this is caused by a true interaction between them or is due to simple saturation of the inhibitory effects that occur at common cortical elements which both inhibitory systems target. We addressed this question by recording the descending corticospinal waves in the subjects with implanted epidural electrodes. The results suggest that there are inhibitory interactions between LICI and SICI.